P.078 Children with Trisomy 21 and Lennox-Gastaut Syndrome with predominant myoclonic seizures

Background: Lennox-Gastaut syndrome (LGS) is a severe form of pediatric epilepsy that classically defined by triad drug-resistant seizures, characteristic EEG patterns, and intellectual disability. Long-term prognosis generally poor with progressive deterioration persistent seizures. At present, there are few reported cases LGS Trisomy 21 (T21) in the literature. To further delineate spectrum T21, we reviewed children T21 at one center over 28 years. Methods: This retrospective case series. our institution, all results entered into database, which was queried for patients from 1992-2019. Pertinent electro-clinical data obtained medical records. Results: 63 epilepsy, 6 (10%) had were included study. Four six male 5/6, neuro-imaging, normal. Follow-up ranged 3-20 Notably, 5/6 predominant myoclonic seizures throughout course their associated generalized spike-wave discharges. Conclusions: Myoclonic appear to be seizure type suggestive may have unique pattern LGS.